Noncontact diffuse correlation spectroscopy for noninvasive deep tissue blood flow measurement

Lin, Yu; He, Lian; Shang, Yu; Yu, Guoqiang

doi:doi:10.1117/1.JBO.17.1.010502

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Journal of Biomedical Optics / Volume 17 / Issue 1 / JBO Letters

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Noncontact diffuse correlation spectroscopy for noninvasive deep tissue blood flow measurement

J. Biomed. Opt. 17, 010502 (Feb 03, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.010502

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Abstract

References (8)

Yu Lin, Lian He, Yu Shang, and Guoqiang Yu

University of Kentucky, Center for Biomedical Engineering, Lexington, Kentucky 40506

A noncontact diffuse correlation spectroscopy (DCS) probe has been developed using two separated optical paths for the source and detector. This unique design avoids the interference between the source and detector and allows large source-detector separations for deep tissue blood flow measurements. The noncontact probe has been calibrated against a contact probe in a tissue-like phantom solution and human muscle tissues; flow changes concurrently measured by the two probes are highly correlated in both phantom (R² = 0.89, p<10⁻⁵) and real-tissue (R² = 0.77, p<10⁻⁵, n = 9) tests. The noncontact DCS holds promise for measuring blood flow in vulnerable (e.g., pressure ulcer) and soft (e.g., breast) tissues without distorting tissue hemodynamic properties.

History

Received Oct 14, 2011
Revised Dec 01, 2011
Published online Feb 03, 2012

Digital Object Identifier

http://dx.doi.org/10.1117/1.JBO.17.1.010502

Citation

Yu Lin, Lian He, Yu Shang and Guoqiang Yu, "Noncontact diffuse correlation spectroscopy for noninvasive deep tissue blood flow measurement", J. Biomed. Opt. 17, 010502 (Feb 03, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.010502

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