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Journal of Biomedical Optics / Volume 17 / Issue 1 / Review Papers

Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring

J. Biomed. Opt. 17, 010901 (Feb 07, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.010901

Guoqiang Yu

University of Kentucky, Center for Biomedical Engineering, Lexington, Kentucky 40506-0070

A novel near-infrared (NIR) diffuse correlation spectroscopy (DCS) for tumor blood flow measurement is introduced in this review paper. DCS measures speckle fluctuations of NIR diffuse light in tissue, which are sensitive to the motions of red blood cells. DCS offers several attractive new features for tumor blood flow measurement such as noninvasiveness, portability, high temporal resolution, and relatively large penetration depth. DCS technology has been utilized for continuous measurement of tumor blood flow before, during, and after cancer therapies. In those pilot investigations, DCS hemodynamic measurements add important new variables into the mix for differentiation of benign from malignant tumors and for prediction of treatment outcomes. It is envisaged that with more clinical applications in large patient populations, DCS might emerge as an important method of choice for bedside management of cancer therapy, and it will certainly provide important new information about cancer physiology that may be of use in diagnosis.

© 2012 Society of Photo-Optical Instrumentation Engineers

History
Received Aug 04, 2011
Accepted Nov 14, 2011
Revised Nov 08, 2011
Published online Feb 07, 2012
Digital Object Identifier
http://dx.doi.org/10.1117/1.JBO.17.1.010901
Citation
Guoqiang Yu, "Near-infrared diffuse correlation spectroscopy in cancer diagnosis and therapy monitoring", J. Biomed. Opt. 17, 010901 (Feb 07, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.010901

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