Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma

Lange-Asschenfeldt, Susanne; Babilli, Jasmin; Beyer, Marc; Ríus-Diaz, Francisca; González, Salvador; Stockfleth, Eggert; Ulrich, Martina

doi:doi:10.1117/1.JBO.17.1.016001

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Journal of Biomedical Optics / Volume 17 / Issue 1 / Research Papers: Imaging

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Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma

J. Biomed. Opt. 17, 016001 (Jan 31, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.016001

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Abstract

References (19)

Susanne Lange-Asschenfeldt, Jasmin Babilli, Marc Beyer, Eggert Stockfleth, and Martina Ulrich

Universitätsmedizin Charité, Department of Dermatology, Berlin, Germany

Francisca Ríus-Diaz

University of Malaga, Department of Biostatistics, Malaga, Spain

Salvador González

Memorial Sloan Kettering Cancer Center, Division of Dermatology, New York, New York

Reflectance confocal microscopy (RCM) represents a noninvasive imaging technique that has previously been used for characterization of mycosis fungoides (MF) in a pilot study. We aimed to test the applicability of RCM for diagnosis and differential diagnosis of MF in a clinical study. A total of 39 test sites of 15 patients with a biopsy-proven diagnosis of either MF, parapsoriasis, Sézary syndrome, or lymphomatoid papulosis were analyzed for presence and absence of RCM features of MF. Cochran and Chi² analysis were applied to test the concordance between investigators and the distribution of RCM features, respectively. For selected parameters, the Cochran analysis showed good concordance between investigators. Inter-observer reproducibility was highest for junctional atypical lymphocytes, architectural disarray, and spongiosis. Similarly, Chi² analysis demonstrated that selected features were present at particularly high frequency in individual skin diseases, with values ranging from 73% to 100% of all examined cases.

History

Received Sep 19, 2011
Revised Oct 28, 2011
Published online Jan 31, 2012

Digital Object Identifier

http://dx.doi.org/10.1117/1.JBO.17.1.016001

Citation

Susanne Lange-Asschenfeldt, Jasmin Babilli, Marc Beyer, Francisca Ríus-Diaz, Salvador González, Eggert Stockfleth and Martina Ulrich, "Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma", J. Biomed. Opt. 17, 016001 (Jan 31, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.016001