Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy

Suzuki, Yusuke; Maruo, Katsuhiko; Zhang, Alice W.; Shimogaki, Kazushige; Ogawa, Hideto; Hirayama, Fumiya

doi:doi:10.1117/1.JBO.17.1.017004

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Journal of Biomedical Optics / Volume 17 / Issue 1 / Research Papers: Sensing

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Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy

J. Biomed. Opt. 17, 017004 (Feb 07, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.017004

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Abstract

References (24)

Yusuke Suzuki and Katsuhiko Maruo

Panasonic Electric Works Co., Ltd., Advanced Technologies Development Laboratory, 1048, Kadoma Kadoma-city, Osaka 571-8686, Japan

Alice W. Zhang

University of British Columbia, Department of Psychology, 2029—2136 West Mall, Vancouver, British Columbia V6T 1Z4, Canada

Kazushige Shimogaki, Hideto Ogawa, and Fumiya Hirayama

Osaka Red Cross Blood Center, 2-4-43, Morinomiya Jyotouku Osaka-city, Osaka 536-0025, Japan

Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components. Hence this study is aimed to serve as a preliminary study for the nondestructive measurement of glucose level in transfusion blood. The glucose concentrations in red blood cell (RBC) samples were predicted using near-infrared diffuse-reflectance spectroscopy in the 1350 to 1850 nm wavelength region. Furthermore, the effects of donor, hematocrit level, and temperature variations among the RBC samples were observed. Results showed that the prediction performance of a dataset which contained samples that differed in all three parameters had a standard error of 29.3 mg/dL. Multiplicative scatter correction (MSC) preprocessing method was also found to be effective in minimizing the variations in scattering patterns created by various sample properties. The results suggest that the diffuse-reflectance spectroscopy may provide another avenue for the detection of bacterial contamination in red cell concentrations (RCC) products.

History

Received Aug 30, 2011
Accepted Nov 28, 2011
Revised Nov 21, 2011
Published online Feb 07, 2012

Digital Object Identifier

http://dx.doi.org/10.1117/1.JBO.17.1.017004

Citation

Yusuke Suzuki, Katsuhiko Maruo, Alice W. Zhang, Kazushige Shimogaki, Hideto Ogawa and Fumiya Hirayama, "Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy", J. Biomed. Opt. 17, 017004 (Feb 07, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.017004