Magnetic field enriched surface enhanced resonance Raman spectroscopy for early malaria diagnosis

Yuen, Clement; Liu, Quan

doi:doi:10.1117/1.JBO.17.1.017005

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Journal of Biomedical Optics / Volume 17 / Issue 1 / Research Papers: Sensing

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Magnetic field enriched surface enhanced resonance Raman spectroscopy for early malaria diagnosis

J. Biomed. Opt. 17, 017005 (Feb 07, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.017005

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Abstract

References (40)

Clement Yuen and Quan Liu

Nanyang Technological University, Division of Bioengineering, School of Chemical and Biomedical Engineering, Singapore 637457

Hemozoin is a by-product of malaria infection in erythrocytes, which has been explored as a biomarker for early malaria diagnosis. We report magnetic field-enriched surface-enhanced resonance Raman spectroscopy (SERRS) of β—hematin crystals, which are the equivalent of hemozoin biocrystals in spectroscopic features, by using magnetic nanoparticles with iron oxide core and silver shell (Fe₃O₄@Ag). The external magnetic field enriches β—hematin crystals and enhances the binding between β—hematin crystals and magnetic nanoparticles, which provides further improvement in SERRS signals. The magnetic field-enriched SERRS signal of β—hematin crystals shows approximately five orders of magnitude enhancement in the resonance Raman signal, in comparison to about three orders of magnitude improvement in the SERRS signal without the influence of magnetic field. The improvement has led to a β—hematin detection limit at a concentration of 5 nM (roughly equivalent to 30 parasites/μl at the early stages of malaria infection), which demonstrates the potential of magnetic field-enriched SERRS technique in early malaria diagnosis.

History

Received Aug 27, 2011
Accepted Nov 30, 2011
Revised Nov 18, 2011
Published online Feb 07, 2012

Digital Object Identifier

http://dx.doi.org/10.1117/1.JBO.17.1.017005

Citation

Clement Yuen and Quan Liu, "Magnetic field enriched surface enhanced resonance Raman spectroscopy for early malaria diagnosis", J. Biomed. Opt. 17, 017005 (Feb 07, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.017005