Magnetic-field-assisted photothermal therapy of cancer cells using Fe-doped carbon nanoparticles

Gu, Ling; Vardarajan, Vijaylakshmi; Koymen, Ali R.; Mohanty, Samarendra K.

doi:doi:10.1117/1.JBO.17.1.018003

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Journal of Biomedical Optics / Volume 17 / Issue 1 / Research Papers: Therapeutic

J. Biomed. Opt. 17, 018003 (Feb 06, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.018003

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Abstract

References (38)

Ling Gu, Vijaylakshmi Vardarajan, Ali R. Koymen, and Samarendra K. Mohanty

University of Texas at Arlington, Department of Physics, Texas 76019

Photothermal therapy with assistance of nanoparticles offers a solution for the destruction of cancer cells without significant collateral damage to otherwise healthy cells. However, minimizing the required number of injected nanoparticles is a major challenge. Here, we introduce the use of magnetic carbon nanoparticles (MCNPs), localizing them in a desired region by applying an external magnetic-field, and irradiating the targeted cancer cells with a near-infrared laser beam. The MCNPs were prepared in benzene, using an electric plasma discharge, generated in the cavitation field of an ultrasonic horn. The CNPs were made ferromagnetic by use of Fe-electrodes to dope the CNPs, as confirmed by magnetometry. Transmission electron microscopy measurements showed the size distribution of these MCNPs to be in the range of 5 to 10 nm. For photothermal irradiation, a tunable continuous wave Ti: Sapphire laser beam was weakly focused on to the cell monolayer under an inverted fluorescence microscope. The response of different cell types to photothermal irradiation was investigated. Cell death in the presence of both MCNPs and laser beam was confirmed by morphological changes and propidium iodide fluorescence inclusion assay. The results of our study suggest that MCNP based photothermal therapy is a promising approach to remotely guide photothermal therapy.

History

Received May 21, 2011
Accepted Nov 23, 2011
Revised Nov 22, 2011
Published online Feb 06, 2012

Digital Object Identifier

http://dx.doi.org/10.1117/1.JBO.17.1.018003

Citation

Ling Gu, Vijaylakshmi Vardarajan, Ali R. Koymen and Samarendra K. Mohanty, "Magnetic-field-assisted photothermal therapy of cancer cells using Fe-doped carbon nanoparticles", J. Biomed. Opt. 17, 018003 (Feb 06, 2012); http://dx.doi.org/10.1117/1.JBO.17.1.018003