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Silicon-based hybrid luminescent/magnetic porous nanoparticles for biomedical applications

J. Nanophoton. 5, 051505 (Feb 04, 2011); http://dx.doi.org/10.1117/1.3549739

Álvaro Muñoz-Noval, Vicente Torres-Costa, Darío Gallach, Miguel Manso-Silván, and Raúl J. Martín-Palma

Universidad Autónoma de Madrid, Departamento de Física Aplicada and Centro de Investigaciones Biomédicas en Red, Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28049 Cantoblanco, Madrid, Spain

Vanessa Sánchez-Vaquero and Josefa P. García-Ruiz

Universidad Autónoma de Madrid, Departamento de Biología Molecular and Centro de Investigaciones Biomédicas en Red, Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28049 Cantoblanco, Madrid, Spain

M. Hernando-Pérez and P. J. de Pablo

Universidad Autónoma de Madrid, Departamento de Física de la Materia Condensada,28049 Cantoblanco, Madrid, Spain

Silicon-based porous nanoparticles showing at the same time intense visible luminescence and magnetic response were fabricated. The hybrid luminescent/magnetic nanoparticles (hLMNPs) were fabricated by the electrodeposition of cobalt and iron into nanostructured porous silicon. These nanoparticles were subsequently functionalized and internalized into cells. The hybrid behavior of the hLMNPs is a relevant feature for the development of research tools as nontoxic cellular tracker for progenitor cells and consequently able to be used in many strategies of cellular therapy. Additionally, the hLMNPs can be functionalized with various biomolecules that will endow them with new functionalities.

© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

History
Received Oct 01, 2010
Accepted Dec 28, 2010
Revised Nov 23, 2010
Published online Feb 04, 2011
Corrected Mar 03, 2011
Citation
Álvaro Muñoz-Noval, Vanessa Sánchez-Vaquero, Vicente Torres-Costa, Darío Gallach, Miguel Manso-Silván, Josefa P. García-Ruiz, M. Hernando-Pérez, P. J. de Pablo and Raúl J. Martín-Palma, "Silicon-based hybrid luminescent/magnetic porous nanoparticles for biomedical applications", J. Nanophoton. 5, 051505 (Feb 04, 2011); http://dx.doi.org/10.1117/1.3549739

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