Numerical simulation validation of nonuniform, nonharmonic analysis of spectral-domain optical coherence tomography

Tetsuya Uchida; Yuya Inuzuka; Masaya Hasegawa; Shigeki Hirobayashi; Tadanobu Misawa

doi:10.1117/1.OE.54.3.033108

25 March 2015 Numerical simulation validation of nonuniform, nonharmonic analysis of spectral-domain optical coherence tomography

Tetsuya Uchida, Yuya Inuzuka, Masaya Hasegawa, Shigeki Hirobayashi, Tadanobu Misawa

Author Affiliations +

Optical Engineering, Vol. 54, Issue 3, 033108 (March 2015). https://doi.org/10.1117/1.OE.54.3.033108

Abstract

In spectral-domain optical coherence tomography (SD-OCT), the limited resolution of the spectrometer causes nonuniformity of the interference signal. The latter, in turn, causes the sensitivity of SD-OCT to decrease, thereby limiting the imaging range and decreasing the axial resolution. We addressed this problem by applying nonuniform, nonharmonic analysis (NUNHA) with software that features high-frequency resolution without interpolation. We demonstrate the application of NUNHA in SD-OCT and compare it with conventional frequency analysis methods by simulating nonuniform interference signals. The results suggest that application of NUNHA in SD-OCT can provide acquisition of a clearer tomographic image, accurate analysis of fine and complex structures, and preservation of resolution and sensitivity at regions deep within a sample. This is because it reduces the influence of nonuniformity caused by the spectrometer and is unaffected by distortion due to interpolation.

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Tetsuya Uchida, Yuya Inuzuka, Masaya Hasegawa, Shigeki Hirobayashi, and Tadanobu Misawa "Numerical simulation validation of nonuniform, nonharmonic analysis of spectral-domain optical coherence tomography," Optical Engineering 54(3), 033108 (25 March 2015). https://doi.org/10.1117/1.OE.54.3.033108

Published: 25 March 2015

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