Using OCT-based microangiography for in vivo longitudinal study of arteriogenesis (Conference Presentation)

Yuandong Li; Woo June Choi; Ruikang K. Wang

doi:10.1117/12.2253285

19 April 2017 Using OCT-based microangiography for in vivo longitudinal study of arteriogenesis (Conference Presentation)

Yuandong Li, Woo June Choi, Ruikang K. Wang

Author Affiliations +

Proceedings Volume 10063, Dynamics and Fluctuations in Biomedical Photonics XIV; 100630F (2017) https://doi.org/10.1117/12.2253285
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

The adaptive growth of collateral vessels, termed “arteriogenesis”, is crucial for maintaining regional blood supply during arterial obstruction and offsetting the adverse effect of tissue ischemia. Stimulation of arteriogenesis has been applied for the treatment of occlusive vascular diseases, and in vivo imaging of the progressive development of collateral vessel will facilitate a better understanding of the mechanism. We present using high-resolution OCT-based microangiography (OMAG) to image arteriogenesis process longitudinally in mouse cerebral cortex after middle cerebral artery occlusion (MCAO). We imaged the collateral arterioles at the arteriolo-arteriolar anastomosis (AAA) within 7-day period after MCAO to reveal key elements of collateral vessel remodeling, including alteration in vessel morphology, velocity and directionality of blood flow. The magnitudes of changes in these parameters matched the time course of the active building of collateral vessels stated in previous studies using histology. Hence, OMAG is a promising imaging tool for non-invasive longitudinal study of functional collateral vessel growth in small animal models and can be potentially applied in the experimental study of arteriogenesis stimulation.

Conference Presentation

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Yuandong Li, Woo June Choi, and Ruikang K. Wang "Using OCT-based microangiography for in vivo longitudinal study of arteriogenesis (Conference Presentation)", Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100630F (19 April 2017); https://doi.org/10.1117/12.2253285

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