Registration-based regional lung mechanical analysis: retrospectively reconstructed dynamic imaging versus static breath-hold image acquisition

Ding, Kai; Cao, Kunlin; Christensen, Gary E.; Hoffman, Eric A.; Reinhardt, Joseph M.

doi:doi:10.1117/12.813694

My Subscription | My Email Alerts | My Article Collections

BROWSE PROCEEDINGS

Proceedings

BROWSE JOURNALS

Journals

BROWSE SPIE eBOOKS

SPIE eBooks

SUBSCRIPTIONS & PRICING

GENERAL INFORMATION

You are not logged in Logged Out Log In

Proceedings / Volume 7262 / Lung

Previous Article | Next Article

Registration-based regional lung mechanical analysis: retrospectively reconstructed dynamic imaging versus static breath-hold image acquisition

Proc. SPIE 7262, 72620D (2009); doi:10.1117/12.813694

Sunday 8 February 2009

Lake Buena Vista, FL, USA

Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging

Xiaoping P. Hu, Anne V. Clough

Alerts
- Alert Me When Cited
- Alert Me When Corrected
Tools
Share
- Email Abstract
- Connotea
- CiteULike
- del.icio.us
- BibSonomy
- Tweet this Article
- Add to Facebook

Abstract

References (21)

Citing Articles (1)

Kai Ding, Kunlin Cao, Gary E. Christensen, Eric A. Hoffman, and Joseph M. Reinhardt

The Univ. of Iowa (USA)

The lungs undergo expansion and contraction during the respiratory cycle. Since many disease or injury conditions are associated with the biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation and regional mechanical changes. We describe a technique that uses multiple respiratory-gated CT images and non-rigid 3D image registration to make local estimates of lung tissue expansion. The degree of regional lung expansion is measured using the Jacobian (a function of local partial derivatives) of the registration displacement field. We compare the ventral-dorsal patterns of lung expansion estimated in both retrospectively reconstructed dynamic scans and static breath-hold scans to a xenon CT based measure of specific ventilation and a semi-automatic reference standard in four anesthetized sheep studied in the supine orientation. The regional lung expansion estimated by 3D image registration of images acquired at 50% and 75% phase points of the inspiratory portion of the respiratory cycle and 20 cm H₂O and 25 cm H₂O airway pressures gave the best match between the average Jacobian and the xenon CT specific ventilation respectively (linear regression, average r² = 0.85 and r² = 0.84). The registration accuracy assessed by 200 semi-automatically matched landmarks in both the dynamic and static scans show landmark error on the order of 2 mm.

History

Online Feb 27, 2009

Permalink

http://dx.doi.org/10.1117/12.813694

Citation

Kai Ding, Kunlin Cao, Gary E. Christensen, Eric A. Hoffman and Joseph M. Reinhardt, "Registration-based regional lung mechanical analysis: retrospectively reconstructed dynamic imaging versus static breath-hold image acquisition", Proc. SPIE 7262, 72620D (2009); doi:10.1117/12.813694