The adoption of artificial intelligence and digital pathology shows immense promise for transforming healthcare through enhanced efficiency, cost-effectiveness, and patient outcomes. However, real-world clinical deployment of deep learning systems faces major obstacles, including the significant staining variability inherent to histopathology workflows. Differences in protocols, reagents, and scanners cause considerable distribution shifts that undermine model generalization.
Deep learning based techniques have been widely used for semantic segmentation. The underlying voluminous DNN models are trained on large datasets that have been annotated at the pixel level by humans. Such low-level annotation tasks are expensive to obtain for newly collected datasets. Alternatively, we propose ComViSe, a segmentation pipeline that requires only high-level annotations that remain relatively accessible (e.g., bounding boxes and labels of a detection, labels of a legend) to segment a given image. ComViSe embeds a segmentation framework, pre-trained on a semantically different dataset, to generate image region proposals. The pipeline relies then on several semantic, visual and geometric criteria to characterize each proposed region, and combines them to select the optimal segmentation mask, comparing diverse aggregation strategies from handcrafted formula to automatic ones, supervised or not. An experimental study conducted on the PASCAL VOC dataset shows that these effectively combined criteria are enough to select the mask proposals with the best IoU score in most cases, and that the aggregation can be done automatically.
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