Dr. Faiza Asghar Profile

Dr. Faiza Asghar

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Proceedings Article | 1 July 2021 Paper

Synthesis spectroscopic investigation and pharmacological evaluation of metal complex containing O, S donor ligand

Bushra Shakoor, Faiza Asghar

Proceedings Volume 11877, 1187709 (2021) https://doi.org/10.1117/12.2600495

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Thiourea, an O and S containing compound, is an important reagent in organic synthesis, used as a source of sulphides, acts as a reactant in synthesis of many heterocyclic compounds. The presence of O and S donor atoms offers a multitude of bonding possibilities, enables them to act as versatile ligands and form stable complexes. The purpose of this research work was to synthesize the transition metal complex of acyl derivative possessing oxygen and sulfur donor atoms that can act as efficient antibacterial and antifungal agents. An O, S donor ligand was prepared by the reaction between isothiocyanate and substituted amine. Metal complex of this bidentate ligand was synthesized by the reaction between metal salt and ligand. Zinc based thiourea such as: 3-(4-bromobenzoyl)-1-ethyl-1-(4-fluorophenyl) thiourea display a broad spectrum of biological applications. Acyl derivative and its complex was structurally analyzed by Fourier transform infrared spectroscopy and elemental analysis. Biological activity was checked by preparing different culture media.

Proceedings Article | 1 July 2021 Paper

Synthesis, structural interpretation, and DFT study of potentially bioactive metal complexes of acyl thiocarbamides

Muzzamil Shamshi, Faiza Asghar

Proceedings Volume 11877, 1187707 (2021) https://doi.org/10.1117/12.2600477

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A novel metal complex of acyl thiocarbamide ligand has been synthesized to study the biological activity of this metal complex. These compounds show a wide variety of biological applications, such as antiviral, antibacterial, antifungal and antitubercular. The presence of nitrogen and sulfur donor atoms provides a multitude of bonding possibilities, which enables them to act as versatile ligands. So the novel acyl thiocarbamide ligand was synthesized by reacting potassium thiocyanate with the derivatives of acid chlorides and substituted anilines. Then metal complex was prepared by reacting synthesized acyl thiocarbamide ligand with metal salts in methanol. The obtained products were characterized by FTIR spectroscopy and DFT study. Energies and distribution of charge on molecular structure was calculated through DFT study. Nickel based acyl thiocarbamide such as: 1-(4-nitrophenyl)-3-(3-methoxy benzoyl) thiocarbamide has highest bioactivity against antimicrobial and have been assayed against gram negative strains including Enterobacter aerogenes and salmonella typhimurium. The coordination between acylthiocarbamide derivatives proceeded by an exchange reaction, which involved deprotonation of the acyl thioureido group of the ligands during the complexes formation.

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