Prof. Mohsen Akbari Profile

Prof. Mohsen Akbari

at University of Victoria

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Proceedings Article | 6 March 2023 Presentation

Engineered microtissues for disease modelling and drug screening

Mohsen Akbari

Proceedings Volume PC12374, PC1237408 (2023) https://doi.org/10.1117/12.2657740

KEYWORDS: 3D modeling, Modeling, Animal model studies, Tissues, Tumor growth modeling, Therapeutics, Stereolithography, Skin, Printing, Pre-clinical research

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Pre-clinical research is often conducted in two-dimensional (2D) cancer cell cultures or in animal models to identify the molecular pathways that underlie the onset and course of a disease or to assess the effectiveness of experimental therapies. However, the reductionist 2D method may distort interactions between cells and integrins and does not recreate 3D cell morphology or match the natural in situ environment of tissues. Despite the fact that animal models offer the natural 3D milieu in which cells reside, interspecies differences, cost, and ethical concerns continue to be important barriers to the development of these models. Therefore, there is a critical need for creating bioengineered in vitro models that can use biomaterials and cells obtained from humans to replicate the 3D cytostructure and microenvironment of diseases. In this talk, I will give an overview of our work on microphysiological tissue models for drug screening in this lecture. To this end, I will discuss the c

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