Dr. Russell S. Witte Profile

Dr. Russell S. Witte

Associate Professor of Radiology at Univ of Arizona College of Medicine

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Author

Publications (22)

SPIE Journal Paper | 14 November 2023 Open Access

Heavy water coupling gel for short-wave infrared photoacoustic imaging

Christopher Salinas, Eric Reichel, Abhiman Gupta, Russell Witte

JBO, Vol. 28, Issue 11, 116001, (November 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.11.116001

KEYWORDS: Short wave infrared radiation, Reflection, Tissues, Photoacoustic imaging, Infrared radiation, Infrared imaging, Ultrasonography, Infrared photography, Acoustics, Absorption

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SPIE Journal Paper | 13 February 2017 Open Access

Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy

Kenneth Furdella, Russell Witte, Jonathan Vande Geest

JBO, Vol. 22, Issue 04, 041016, (February 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.041016

KEYWORDS: Heart, Diffusion, Arteries, Photoacoustic spectroscopy, Absorption, Tissues, Photoacoustic imaging, Imaging spectroscopy, Spectroscopy, Tissue optics

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Proceedings Article | 25 February 2012 Paper

Ultrasound imaging of the mouse pancreatic duct using lipid microbubbles

B. Banerjee, K. McKeown, B. Skovan, E. Ogram, P. Ingram, N. Ignatenko, G. Paine-Murrieta, R. Witte, T. Matsunaga

Proceedings Volume 8320, 832018 (2012) https://doi.org/10.1117/12.902635

KEYWORDS: Ultrasonography, Cancer, Pancreas, Image resolution, Pancreatic cancer, Pathology, Scattering, Endoscopy, Biomedical optics, Medical research

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SPIE Journal Paper | 1 February 2011 Open Access

3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window

Daniel Bauer, Ragnar Olafsson, Leonardo Montilla, Russell Witte

JBO, Vol. 16, Issue 02, 026012, (February 2011) https://doi.org/10.1117/12.10.1117/1.3540668

KEYWORDS: Tumors, Skin, Tissue optics, Photoacoustic spectroscopy, Cancer, Blood vessels, 3D image processing, Prostate, Photography, Imaging systems

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Proceedings Article | 12 March 2010 Paper

Detection of multiple electrical sources in tissue using ultrasound current source density imaging

Zhaohui Wang, Pier Ingram, Ragnar Olafsson, Qian Li, Russell Witte

Proceedings Volume 7629, 76290H (2010) https://doi.org/10.1117/12.844657

KEYWORDS: Tissues, Ultrasonography, Signal detection, Transducers, Bridges, 3D image processing, Acoustics, Spatial resolution, Electrodes, Natural surfaces

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Proceedings Article | 12 March 2010 Paper

Simulation-based optimization of the acoustoelectric hydrophone for mapping an ultrasound beam

Zhaohui Wang, Pier Ingram, Ragnar Olafsson, Charles Greenlee, Robert Norwood, Russell Witte

Proceedings Volume 7629, 76290Q (2010) https://doi.org/10.1117/12.844651

KEYWORDS: Ultrasonography, Transducers, Optical simulations, Signal to noise ratio, Gold, Signal detection, Fourier transforms, Acoustics, Electrodes, Interference (communication)

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Proceedings Article | 12 March 2010 Paper

Fabrication and characterization of an indium tin oxide acoustoelectric hydrophone

Pier Ingram, Charles Greenlee, Zhaohui Wang, Ragnar Olafsson, Robert Norwood, Russell Witte

Proceedings Volume 7629, 76290O (2010) https://doi.org/10.1117/12.845631

KEYWORDS: Transducers, Gold, Electrodes, Ultrasonography, Acoustics, Sensors, Indium, Tin, Oxides, Imaging arrays

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Proceedings Article | 24 February 2010 Paper

In vivo multi-modality photoacoustic and pulse echo tracking of prostate tumor growth using a window chamber

Daniel Bauer, Ragnar Olafsson, Leonardo Montilla, Russell Witte

Proceedings Volume 7564, 75643B (2010) https://doi.org/10.1117/12.843875

KEYWORDS: Tumors, Skin, Photoacoustic spectroscopy, Green fluorescent protein, Tissue optics, Cancer, Imaging systems, Ultrasonography, Tissues, Transducers

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Proceedings Article | 23 February 2010 Paper

Real-time pulse echo and photoacoustic imaging using an ultrasound array and in-line reflective illumination

Leonardo Montilla, Ragnar Olafsson, Russell Witte

Proceedings Volume 7564, 75643C (2010) https://doi.org/10.1117/12.843877

KEYWORDS: Reflectors, Ultrasonography, Transducers, Acoustics, Prisms, Imaging systems, Transparency, Photoacoustic spectroscopy, Breast cancer, Tissues

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Proceedings Article | 25 February 2009 Paper

Tracking contrast agents using real-time 2D photoacoustic imaging system for cardiac applications

Ragnar Olafsson, Leonardo Montilla, Pier Ingram, Russell Witte

Proceedings Volume 7177, 71771R (2009) https://doi.org/10.1117/12.811060

KEYWORDS: Heart, Imaging systems, Photoacoustic spectroscopy, Ultrasonography, Scanners, Photoacoustic imaging, Data acquisition, Ultrasonics, Spatial resolution, Laser scanners

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SPIE Journal Paper | 1 November 2008 Open Access

Thin polymer etalon arrays for high-resolution photoacoustic imaging

Yang Hou, Sheng-Wen Huang, Shai Ashkenazi, Russell Witte, Matthew O'Donnell

JBO, Vol. 13, Issue 06, 064033, (November 2008) https://doi.org/10.1117/12.10.1117/1.3042260

KEYWORDS: Fabry–Perot interferometers, Ultrasonography, Photoacoustic imaging, Transducers, Polymers, Acoustics, 3D image processing, Laser beam diagnostics, Ferroelectric polymers, Signal detection

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Proceedings Article | 28 February 2008 Paper

Enhanced photoacoustic neuroimaging with gold nanorods and PEBBLEs

Russell Witte, K. Kim, A. Agarwal, W. Fan, R. Kopelman, N. Kotov, D. Kipke, M. O'Donnell

Proceedings Volume 6856, 685614 (2008) https://doi.org/10.1117/12.764337

KEYWORDS: Nerve, Photoacoustic spectroscopy, Tissue optics, Absorption, Gold, Neuroimaging, Brain, Tissues, In vivo imaging, Nanorods

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Proceedings Article | 28 February 2008 Paper

In vivo imaging of inflammatory responses by photoacoustics using cell-targeted gold nanorods (GNR) as contrast agent

K. Kim, A. Agarwal, A. Mcdonald, R. Moore, D. Myers, R. Witte, S.-W. Huang, S. Ashkenazi, M. Kaplan, T. Wakefield, M. O'Donnell, N. Kotov

Proceedings Volume 6856, 68560H (2008) https://doi.org/10.1117/12.763498

KEYWORDS: Injuries, Photoacoustic spectroscopy, Ultrasonography, Inflammation, Gold, Veins, Blood, Absorption, In vivo imaging, Nanorods

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Proceedings Article | 12 March 2007 Paper

Measurement of a 2D electric dipole field using the acousto-electric effect

Ragnar Olafsson, Russell Witte, Matthew O'Donnell

Proceedings Volume 6513, 65130S (2007) https://doi.org/10.1117/12.712448

KEYWORDS: Electrodes, Lead, Ultrasonography, Transducers, Spatial resolution, Acoustics, Electrocardiography, Amplifiers, Heart, Raster graphics

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Proceedings Article | 13 February 2007 Paper

Contrast-enhanced photoacoustic imaging of live lobster nerve cord

Russell Witte, S. Huang, S. Ashkenazi, K. Kim, M. O'Donnell

Proceedings Volume 6437, 64370J (2007) https://doi.org/10.1117/12.701570

KEYWORDS: Photoacoustic spectroscopy, Nerve, Photoacoustic imaging, Ultrasonography, Imaging systems, Spatial resolution, Absorbance, Optical imaging, Image segmentation, Absorption

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Proceedings Article | 13 February 2007 Paper

Toward fiber-based high-frequency 3D ultrasound imaging

Sheng-Wen Huang, Shai Ashkenazi, Yang Hou, Russell Witte, Matthew O'Donnell

Proceedings Volume 6437, 643728 (2007) https://doi.org/10.1117/12.701305

KEYWORDS: Fabry–Perot interferometers, Ultrasonography, Transducers, 3D image processing, Signal detection, Imaging systems, Acoustics, Reflection, Photoacoustic imaging, Optical scanning systems

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Proceedings Article | 16 March 2006 Paper

Electric current mapping using the acousto-electric effect

Ragnar Olafsson, Russell Witte, Kang Kim, Shai Ashkenazi, Matthew O'Donnell

Proceedings Volume 6147, 61470O (2006) https://doi.org/10.1117/12.655755

KEYWORDS: Electrodes, Ultrasonography, Heart, Signal generators, Electrocardiography, Transducers, Spatial resolution, Modulation, Field programmable gate arrays, Solids

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Proceedings Article | 6 March 2006 Paper

2D optoacoustic array for high resolution imaging

S. Ashkenazi, R. Witte, K. Kim, S.-W. Huang, Y. Hou, M. O'Donnell

Proceedings Volume 6086, 60861H (2006) https://doi.org/10.1117/12.645543

KEYWORDS: Fabry–Perot interferometers, Acoustics, Sensors, Ultrasonography, Signal detection, Image resolution, Polymers, Arteries, Laser beam diagnostics, Reflection

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Proceedings Article | 6 March 2006 Paper

Early detection of dental caries using photoacoustics

K. Kim, R. Witte, I. Koh, S. Ashkenazi, M. O'Donnell

Proceedings Volume 6086, 60860G (2006) https://doi.org/10.1117/12.646455

KEYWORDS: Dental caries, Photoacoustic spectroscopy, Teeth, X-rays, Radiography, Visualization, Transducers, Absorption, Photography, Pulsed laser operation

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For decades, visual, tactile and radiographic examinations have been the standard for diagnosing caries. Nonetheless, the extent of variation in the diagnosis of dental caries is substantial among dental practitioners using these traditional techniques. Therefore, a more reliable standard for detecting incipient caries would be desirable. Using photoacoustics, near-infrared (NIR) optical contrast between sound and carious dental tissues can be relatively easily and accurately detected at ultrasound resolution. In this paper, a pulsed laser (Nd:YAG, Quanta-Ray) was used to probe extracted human molars at different disease stages determined from periapical radiographs. Both fundamental (1064nm) and first harmonic (532nm) pulses (15ns pulse length, 100mJ at fundamental and 9mJ at first harmonic , 10Hz pulse repetition rate) were used to illuminate the occlusal surface of tooth samples placed in a water tank. The photoacoustic signal was recorded with an unfocused wideband single-element piezoelectric transducer (centered at 12 MHz, bandwidth 15 MHz) positioned at small angle (less than 30 degrees) to the laser beam close to the occlusal surface. At the fundamental wavelength, total photoacoustic energy increases from normal to incipient stage disease by as much as a factor of 10. Differences between photoacoustic energy at the fundamental and first harmonic wavelength further indicate spectral absorption changes of the underlying structure with disease progression. Using a focused laser beam, an extracted molar with suspected incipient caries was scanned along the occulusal surface to help localize the caries inside enamel and dentin. The significantly increasing photoacoustic signal at a specific scan line both at fundamental and first harmonic indicates the local development of the incipient caries. The photoacoustic results compare well with visual inspection after layer by layer dissection. Preliminary results demonstrate the feasibility of detecting incipient occlusal and proximal caries. This technique may ultimately allow for continuous monitoring of caries before and during treatment.

Proceedings Article | 21 February 2006 Paper

A novel optical imaging system for investigating sarcomere dynamics in single skeletal muscle fibers

Appaji Panchangam, Russell Witte, Dennis Claflin, Matthew O'Donnell, John Faulkner

Proceedings Volume 6088, 608808 (2006) https://doi.org/10.1117/12.647571

KEYWORDS: Stereolithography, Optical fibers, Diffraction, Injuries, Microfluidics, Transducers, Image segmentation, Fiber lasers, Servomechanisms, Magnesium

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Proceedings Article | 25 April 2005 Paper

High frequency ultrasound imaging using Fabry-Perot optical etalon

S. Ashkenazi, R. Witte, M. O'Donnell

Proceedings Volume 5697, (2005) https://doi.org/10.1117/12.589274

KEYWORDS: Fabry–Perot interferometers, Ultrasonography, Signal detection, Polymers, Image resolution, Transducers, Acoustics, Reflection, Nerve, Ultrasonics

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Optical detection of ultrasound provides a unique and appealing way of forming detector arrays (1D or 2D) using either raster beam scanning or simultaneous array detection exploiting wide area illumination. Etalon based optical techniques are of particular interest, due to their relatively high sensitivity resulting from multiple optical reflections within the resonance structure. Detector arrays formed by etalon based techniques are characterized by high element density and small element active area, which enables high resolution imaging at high ultrasonic frequencies (typically 10-50 MHz). In this paper we present an application of an optical etalon structure for very high frequency ultrasound detection (exceeding 100 MHz). A thin polymer Fabry-Perot etalon (10 μm thickness) has been fabricated using spin coating of polymer photoresist on a glass substrate and gold evaporation forming partially reflecting mirrors on both faces of the polymer layer. The optical resonator formed by the etalon structure has a measured Q-factor of 300. The characteristic broadband response of the optical signal was demonstrated by insonifying the etalon using two different ultrasound transducers and recording the resulting intensity modulation of optical reflection from the etalon. A focused 10 MHz transducer was used for the low MHz frequency region, and a 50 MHz focused transducer was used for the high frequency region. The optical reflection signal was compared to the pulse/echo signal detected by the same ultrasound transducer. The measured signal to noise ratio of the optically detected signal is comparable to that of the pulse/echo signal in both low and high frequency ranges. The etalon detector was integrated in a photoacoustic imaging system. High resolution images of phantom targets and biological tissue (nerve cord) were obtained. The additional information of optical absorption obtained by photoacoustic imaging, along with the high resolution detection of the etalon, offer unique advantages for intravascular and neurological imaging devices.

Proceedings Article | 12 April 2005 Paper

High frequency ultrasound imaging using Fabry-Perot optical etalon

Shai Ashkenazi, Russell Witte, Matthew O'Donnell

Proceedings Volume 5750, (2005) https://doi.org/10.1117/12.596169

KEYWORDS: Fabry–Perot interferometers, Ultrasonography, Acoustics, Image resolution, Sensors, Polymers, Nerve, Signal detection, Detector arrays, Imaging systems

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Showing 5 of 22 publications

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