Mr. Sebastián Ruiz-Lopera Profile

Sebastián Ruiz-Lopera

Graduate Student at Massachusetts General Hospital

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Publications (6)

Proceedings Article | 4 April 2024 Presentation

Probabilistic speckle parametric imaging in optical coherence tomography

Bhaskara Rao Chintada, Sebastian Ruiz Lopera, Brett Bouma, Nestor Uribe-Patarroyo

Proceedings Volume PC12830, PC128300N (2024) https://doi.org/10.1117/12.3005661

KEYWORDS: Speckle, Coherence imaging, Optical coherence tomography, Tissues, Speckle imaging, Optical imaging, Medical statistics, Algorithm development, Structural imaging, Statistical methods

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Proceedings Article | 13 March 2024 Poster

An efficient simulation tool for optical coherence tomography

Sebastián Ruiz-Lopera, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume PC12830, PC128301O (2024) https://doi.org/10.1117/12.3005755

KEYWORDS: Optical coherence tomography, Tissues, Optical simulations, Tomography, Statistical modeling, Light scattering, Image processing, Electromagnetic scattering theory, Data modeling, Biological samples

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Proceedings Article | 13 March 2024 Presentation

Advanced image registration in ophthalmic phase-sensitive optical coherence tomography angiography

Tianhui Jie, Sebastián Ruiz-Lopera, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume PC12830, PC128300K (2024) https://doi.org/10.1117/12.3003767

KEYWORDS: Angiography, Image registration, Optical coherence tomography, Image processing, Tomography, Optical coherence, Computer hardware

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Proceedings Article | 11 August 2023 Paper

Practical volumetric speckle reduction in OCT using deep learning

Bhaskara Rao Chintada, Sebastián Ruiz-Lopera, René Restrepo, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume 12632, 126321F (2023) https://doi.org/10.1117/12.2670781

KEYWORDS: Optical coherence tomography, Speckle, Deep learning, Tomography, Neural networks, Image quality, Image enhancement

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Speckle reduction has been an active topic of interest in the Optical Coherence Tomography (OCT) community and several techniques have been developed ranging from hardware-based methods, conventional image-processing and deep-learning based methods. The main goal of speckle reduction is to improve the diagnostic utility of OCT images by enhancing the image quality, thereby enhancing the visual interpretation of anatomical structures. We have previously introduced a probabilistic despeckling method based on non-local means for OCT—Tomographic Non-local-means despeckling (TNode). We demonstrated that this method efficiently suppresses speckle contrast while preserving tissue structures with dimensions approaching the system resolution. Despite the merits of this method, it is computationally very expensive: processing a typical retinal OCT volume takes a few hours. A much faster version of TNode with close to real-time performance, while keeping with the open source nature of TNode, could find much greater use in the OCT community. Deep learning despeckling methods have been proposed in OCT, including variants of conditional Generative Adversarial Networks (cGAN) and convolutional neural networks CNN. However, most of these methods have used B-scan compounding as a ground truth, which presents significant limitations in terms of speckle reduced tomograms with preservation of resolution. In addition, all these methods have focused on speckle suppression of individual B-scans, and their performance on volumetric tomograms is unclear: the expectation is that three-dimensional manipulations of these processed tomograms (i.e., en face projections) will contain artifacts due to the B-scan-wise processing, disrupting the continuity of tissue structures along the slow-scan axis. In addition, speckle suppression based on individual B-scans cannot provide the neural network with information on volumetric structures in the training data, and thus is expected to perform poorly on small structures. Indeed, most deep-learning despeckling works have focused on image quality metrics based on demonstrating strong speckle suppression, rather than focusing on preservation of contrast and small tissue structures. To overcome these problems, we propose an entire workflow to enable the wide-spread use of deep-learning speckle suppression in OCT: the ground-truth is generated using volumetric TNode despeckling, and the neural network uses a new cGAN that receives OCT partial volumes as inputs to utilize the three-dimensional structural information for speckle reduction. Because of its reliance on TNode for generating ground-truth data, this hybrid deep-learning–TNode (DL-TNode) framework will be made available to the OCT community to enable easy training and implementation in a multitude of OCT systems without relying on specialty-acquired training data.

Proceedings Article | 9 March 2023 Presentation

In-vivo retinal nerve fiber bundle polarimetry with probabilistic Stokes polarization-sensitive optical coherence tomography

Sebastián Ruiz-Lopera, René Restrepo, Martin Villiger, Brett E. Bouma, Néstor Uribe-Patarroyo

Proceedings Volume PC12367, PC1236711 (2023) https://doi.org/10.1117/12.2653011

KEYWORDS: Polarimetry, Optical coherence tomography, Nerve, In vivo imaging, Tissue optics, Eye, Birefringence, Visualization, Therapeutics, Statistical analysis

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Proceedings Article | 5 March 2021 Presentation

Computational refocusing in polarization-sensitive optical coherence tomography with phase unstable systems

Sebastián Ruiz-Lopera, René Restrepo, Taylor Cannon, Martin Villiger, Brett Bouma, Néstor Uribe-Patarroyo

Proceedings Volume 11630, 116300E (2021) https://doi.org/10.1117/12.2583925

KEYWORDS: Optical coherence tomography, Computing systems, Aberration correction, Polarimetry, Image segmentation, Image quality standards, Image quality, Image processing, Image enhancement, Functional imaging

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Showing 5 of 6 publications

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