Prof. Tyrone Porter Profile

Prof. Tyrone Porter

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Proceedings Article | 13 March 2024 Poster + Paper

Rapid production of liposome encapsulated J-aggregates of indocyanine green

Noah Stern, Binita Shrestha, Tyrone Porter

Proceedings Volume 12862, 128620C (2024) https://doi.org/10.1117/12.3001105

KEYWORDS: Particles, Indocyanine green, Photoacoustic spectroscopy, Photoacoustic imaging, Extrusion, Contrast agents, Absorbance

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Liposomal J-Aggregates of Indocyanine Green (L-JA) offer significant advantages over conventionally used monomeric indocyanine green (IcG) for photoacoustic imaging. When compared to IcG, which is often hindered by low circulation time and poor photostability, L-JA are characterized by longer circulation times, vastly improved photostability, elevated absorption at longer wavelengths, and increased photoacoustic signal generation. However, the documented methods for production of L-JA varies widely, which can lead to significant batch variability. We developed an approach to form IcG J-aggregates (IcG-JA) directly in liposomes efficiently and reproducibly at elevated temperatures. Aggregating within fully formed liposomes ensures particle uniformity and allows for the control of J-Aggregate size within the final particle. This technique provides a more robust and facile approach to producing these viable agents.

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