Computed tomography (CT) images-based early disease screening is of high significance for the detection of the occurrence of cancer. It has been demonstrated that lesion detection using deep learning in CT images are significantly effective for the early stage of cancer. In this study, an improved Cascade R-CNN is proposed. In the proposed network, the Feature Pyramid Network (FPN) is introduced to complete automatic computer-aided lesion detection. Based on this trick, numerous tiny lesions in CT images can be well detected. Experimental results on the DeepLesion show that the proposed method can achieve the mAP of 0.598 with a threshold of 0.5 and 85.2% sensitivity with 4 false positives per image.
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