Dr. Youngjae You Profile

Dr. Youngjae You

at SUNY at Buffalo

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Proceedings Article | 13 July 2009 Paper

Conjugate systems using delocalized cationic dyes as a carrier of photosensitizers to mitochondria

Youngjae You, Ethel Ngen, Pallavi Rajaputra

Proceedings Volume 7380, 738064 (2009) https://doi.org/10.1117/12.823010

KEYWORDS: Rhodium, Luminescence, Adaptive optics, Oxygen, Cancer, Absorption, Rhodamine, Photodynamic therapy, Energy transfer, Prototyping

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Following Photofrin, the first generation photosensitizer, several second generation photosensitizers have been developed with improved characteristics. More recently, third generation photosensitizers are proposed to achieve higher selectivity toward cancer cells/ tumor tissue. Elevated mitochondrial membrane potential of malignant cells has tested as a tool for preferential uptake of certain photosensitizers to cancer cells. In the same line, we designed new conjugate systems where delocalized cationic moiety delivers a photosensitizer to mitochondria. To prove our concept, two prototype conjugates (TPP-Rh and TPP-AO) were prepared using two cationic dyes (Rhodamine and Acridine Orange) and a photosensitizer (tetraphenylporphyrin, TPP). The two conjugates generated singlet oxygen quite well. Interestingly, the two conjugates showed higher cellular uptake by mover than 8 times than TPP-OH as well as higher phototoxicity. In particular, TPP-Rh showed closer localization pattern to mitochondria than TPP-OH.

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