Multi-contrast 3D label-free imaging through a multimode fiber without active wave-control

Szu-Yu Lee; Vicente Parot; Brett E. Bouma; Martin Villiger

doi:10.1117/12.2609641

2 March 2022 Multi-contrast 3D label-free imaging through a multimode fiber without active wave-control

Szu-Yu Lee, Vicente Parot, Brett E. Bouma, Martin Villiger

Proceedings Volume PC11969, Adaptive Optics and Wavefront Control for Biological Systems VIII; PC1196903 (2022) https://doi.org/10.1117/12.2609641
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Imaging through optical multimode fibers (MMFs) has the potential to enable hair-thin endoscopes that reduce the invasiveness of imaging deep inside tissues and organs. Current approaches predominantly require active wavefront shaping and fluorescent labeling, which limits their use to preclinical applications and frustrates imaging speed. Here we present a computational approach to reconstruct depth-gated confocal images from reflectance measurements in response to a proximally raster-scanned illumination. We evidence the potential of this approach by demonstrating quantitative phase, dark-field, and polarimetric imaging. Computational imaging through MMF opens a new pathway for minimally invasive imaging in medical diagnosis and biological investigations.

Conference Presentation

Citation Download Citation

Szu-Yu Lee, Vicente Parot, Brett E. Bouma, and Martin Villiger "Multi-contrast 3D label-free imaging through a multimode fiber without active wave-control", Proc. SPIE PC11969, Adaptive Optics and Wavefront Control for Biological Systems VIII, PC1196903 (2 March 2022); https://doi.org/10.1117/12.2609641

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