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7 March 2023 Estimating the optical properties of multi-layered tissue models using structured interrogation frequency-domain near-infrared spectroscopy
Ola S. A. Abdalsalam, Thomas D. O'Sullivan, Scott Howard
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Proceedings Volume PC12376, Optical Tomography and Spectroscopy of Tissue XV; PC1237603 (2023) https://doi.org/10.1117/12.2650962
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Structured interrogation (SI) is a frequency-domain NIRS technique that adjusts the relative phase between intensity-modulated light sources and generates a various spatial pattern of depth sensitivity. It can be used to extract quantitative information from multi-layered tissues. We apply Cramér-Rao lower bound (CRLB) analysis for phase selection. Then, the selected SI phases are used to resolve the optical properties of a fat/muscle tissue model. We found that CRLB is effective for selecting SI phase shift, and a combination of SI measurements and multi-distance measurements can result in an accurate estimation of optical properties and allow for more compact fd-NIRS probes.
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Ola S. A. Abdalsalam, Thomas D. O'Sullivan, and Scott Howard "Estimating the optical properties of multi-layered tissue models using structured interrogation frequency-domain near-infrared spectroscopy", Proc. SPIE PC12376, Optical Tomography and Spectroscopy of Tissue XV, PC1237603 (7 March 2023); https://doi.org/10.1117/12.2650962
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KEYWORDS
Near infrared spectroscopy
Optical properties
Tissue optics
Phase shift keying
Light sources
Modulation
Phase measurement
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