Three-dimensional multimodal brain imaging of ischemic stroke by integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT)

Luca Menozzi; Angela del Aguila; Tri Vu; Chenshuo Ma; Mucong Li; Wei Yang; Junjie Yao

doi:10.1117/12.2649126

9 March 2023 Three-dimensional multimodal brain imaging of ischemic stroke by integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT)

Luca Menozzi, Angela del Aguila, Tri Vu, Chenshuo Ma, Mucong Li, Wei Yang, Junjie Yao

Author Affiliations +

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC1237917 (2023) https://doi.org/10.1117/12.2649126
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We present an experimental ischemic stroke study using our newly-developed multimodal imaging system that integrates photoacoustic computed tomography (PACT), high-frequency ultrasound imaging, and acoustic angiographic tomography, or PAUSAT. PAUSAT is capable of three-dimensional high-frequency ultrasound imaging of the brain morphology, micro-bubble-enabled acoustic angiography of the brain blood perfusion, and multispectral PACT of brain blood oxygenation. PAUSAT was able to clearly show the brain vascular changes after ischemic stroke, including significantly reduced blood perfusion and oxygenation. Using PAUSAT, stroke infarct volume was reliably measured. The PAUSAT results were confirmed by laser speckle imaging and histology.

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Citation Download Citation

Luca Menozzi, Angela del Aguila, Tri Vu, Chenshuo Ma, Mucong Li, Wei Yang, and Junjie Yao "Three-dimensional multimodal brain imaging of ischemic stroke by integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT)", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC1237917 (9 March 2023); https://doi.org/10.1117/12.2649126

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