Virtual histology with total-absorption photoacoustic remote sensing microscopy (Conference Presentation)

Benjamin R. Ecclestone; James Tweel; Marian Boktor; Krystal Li; Lixin Chu; Hager Gaouda; Kevan Bell; Deepak Dinakaran; John Mackey; Parsin Haji Reza

doi:10.1117/12.2650986

9 March 2023 Virtual histology with total-absorption photoacoustic remote sensing microscopy (Conference Presentation)

Benjamin R. Ecclestone, James Tweel, Marian Boktor, Krystal Li, Lixin Chu, Hager Gaouda, Kevan Bell, Deepak Dinakaran, John Mackey, Parsin Haji Reza

Author Affiliations +

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123791W (2023) https://doi.org/10.1117/12.2650986
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

An automated label-free virtual histology microscope using Photoacoustic Remote Sensing (PARS) microscopy is presented. This device features an optimized architecture providing additional contrasts, and enhancements in image quality and SNR over previous PARS virtual histology embodiments. Concurrently, developments in software and signal processing enable automated scanning of tissue specimens within minutes. Finally, AI-based virtual staining facilitates visualizations analogous to current histochemical staining. The diagnostic utility is demonstrated in unprocessed human tissues. Results validated through clinical efficacy studies demonstrate comparable contrast and diagnostic quality to gold standard histological preparations. This represents a significant step towards a clinical system for virtual pathology.

Conference Presentation

Citation Download Citation

Benjamin R. Ecclestone, James Tweel, Marian Boktor, Krystal Li, Lixin Chu, Hager Gaouda, Kevan Bell, Deepak Dinakaran, John Mackey, and Parsin Haji Reza "Virtual histology with total-absorption photoacoustic remote sensing microscopy (Conference Presentation)", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123791W (9 March 2023); https://doi.org/10.1117/12.2650986

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