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9 March 2023 Visually-evoked hemodynamic responses in deep mouse brain using photoacoustic computed tomography
Kai-Wei Chang, Xueding Wang, Kwoon Y. Wong, Guan Xu
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Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123791B (2023) https://doi.org/10.1117/12.2647872
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
In this study, we developed a label-free photoacoustic computed tomography system to monitor the visually-evoked hemodynamic changes in response to retinal photostimulation by flickering white light. The acoustic signals were collected by a 256-element linear ultrasound transducer array with a 10MHz central frequency, and a 750nm pulsed laser with a 10Hz repetition rate was used as the excitation source to avoid stimulating retinal photoreceptors. During the stimulation, the hemodynamic responses within the visual regions, such as the primary visual cortex, superior colliculus, and suprachiasmatic nucleus, have been observed. This demonstrates that our system can examine visually-evoked brain responses, and has the potential to study the brain activities in mouse models of retinal diseases.
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Kai-Wei Chang, Xueding Wang, Kwoon Y. Wong, and Guan Xu "Visually-evoked hemodynamic responses in deep mouse brain using photoacoustic computed tomography", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123791B (9 March 2023); https://doi.org/10.1117/12.2647872
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KEYWORDS
Brain
Visualization
Photoacoustic tomography
Hemodynamics
Transducers
Acoustics
Neuroimaging
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