Retinal blood flow velocity measurement by a high-speed adaptive optics multi-detection mode ophthalmoscope using a digital micromirror device (DMD)

Soohyun Lee; Stacey S. Choi; Ratheesh K. Meleppat; Robert J. Zawadzki; Nathan Doble

doi:10.1117/12.3003388

13 March 2024 Retinal blood flow velocity measurement by a high-speed adaptive optics multi-detection mode ophthalmoscope using a digital micromirror device (DMD)

Soohyun Lee, Stacey S. Choi, Ratheesh K. Meleppat, Robert J. Zawadzki, Nathan Doble

Author Affiliations +

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC1282401 (2024) https://doi.org/10.1117/12.3003388
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Retinal blood flow velocity was measured in human volunteers by a high-speed adaptive optics multi-detection mode ophthalmoscope using a digital micromirror device (DMD). Retinal vascular images under multi-line illumination were captured and post-processed to obtain differential multiply scattered images with frame acquisition rate of 500 Hz. Velocity measurements based on cross-correlation or Radon transform method showed cardiac-dependent pulsatile patterns. The peak velocity was measured in the range of 1.4 mm/s to 11 mm/s depending on the vessels size. Line illumination patterns with two directions, horizontal and vertical lines, were tested to investigate the effect of relative orientation between illumination lines and vessels on contrast of moving cells.

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Soohyun Lee, Stacey S. Choi, Ratheesh K. Meleppat, Robert J. Zawadzki, and Nathan Doble "Retinal blood flow velocity measurement by a high-speed adaptive optics multi-detection mode ophthalmoscope using a digital micromirror device (DMD)", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC1282401 (13 March 2024); https://doi.org/10.1117/12.3003388

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