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Adaptive optics optical coherence tomography (AOOCT) requires a dense sampling of the retina to visualize individual cones in the living human eye. This in turn increases the acquisition time and introduces susceptibility to eye motion artifacts. Here, we present hybrid transformer generative adversarial network (HT-GAN), an artificial intelligence technique that can improve the pixel resolution of images to better reveal cones from sparsely sampled AOOCT volumes. The method can potentially increase the speed of acquisition by four-fold while maintaining the visibility of individual cones despite a lower than ideal pixel sampling.
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Vineeta Das, Andrew J. Bower, Nancy Aguilera, Joanne Li, Zhuolin Liu, Daniel X. Hammer, Alfredo Dubra, Johnny Tam, "Artificial intelligence improves pixel resolution of cones from sparsely sampled AOOCT," Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC1282410 (13 March 2024); https://doi.org/10.1117/12.3000362