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13 March 2024 Optimization of localized ablative immunotherapy for pancreatic cancer treatment
Trisha I. Valerio, Wei R. Chen, Coline Furrer, Jacob Adams
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Proceedings Volume PC12843, Biophotonics and Immune Responses XIX; PC1284306 (2024) https://doi.org/10.1117/12.3003583
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Pancreatic cancer is one of the lethal types of cancer due to its ability to metastasize throughout the body. Despite recent advances in pancreatic cancer research, all the current cancer therapies have severe limitations in treating metastatic pancreatic cancer. Therefore, there is a need for a treatment regimen that can both break the immunosuppressive nature of the tumor and control cancer metastasis. We used a novel localized ablative immunotherapy, a combination of interstitial photothermal therapy (iPTT) and intratumoral administration of immunostimulant, to treat pancreatic tumors in mouse model. Here, we investigated the effects of iPTT on the tumor microenvironment or orthotopic mouse model to determine the optimal ablative effects. This treatment regimen will later be combined with an immunostimulant for a synergistic approach to provide an effective treatment modality for metastatic pancreatic cancers.
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Trisha I. Valerio, Wei R. Chen, Coline Furrer, and Jacob Adams "Optimization of localized ablative immunotherapy for pancreatic cancer treatment", Proc. SPIE PC12843, Biophotonics and Immune Responses XIX, PC1284306 (13 March 2024); https://doi.org/10.1117/12.3003583
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KEYWORDS
Pancreatic cancer
Tumors
Ablation
Cancer
Therapeutics
Oncology
Pancreas
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