Diamond quantum sensors for quantitative detection of iron load in ferritin proteins

David A. Simpson

doi:10.1117/12.3009004

13 March 2024 Diamond quantum sensors for quantitative detection of iron load in ferritin proteins

David A. Simpson

Author Affiliations +

Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC128620A (2024) https://doi.org/10.1117/12.3009004
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The essential role of ferritin in iron homeostasis makes its study highly important for fundamental biochemistry research and clinical analysis of iron status, while the magnetic properties of its core mean that it holds interest for understanding magnetism in nanoscale condensed matter systems. Here we employ an emerging magnetic sensing technique using nitrogen-vacancy fluorescence defects in single crystal diamond and nanodiamonds, to quantify the magnetic properties of the iron core of ferritin as it is loaded. We observe anomalous magnetic behavior that can be explained using a theoretical model detailing a morphological change to the iron core occurring at relatively low iron loads. This model provides an L^(0.35±0.06) scaling of the uncompensated Fe spins, in agreement with previous theoretical predictions. The low detection limit (ferritin 2% loaded at a concentration of 7.5 ± 0.4 μg/mL) also makes this a promising method for precision applications where low analyte concentrations are unavoidable, such as in biological research or even clinical analysis.

Conference Presentation

Citation Download Citation

David A. Simpson "Diamond quantum sensors for quantitative detection of iron load in ferritin proteins", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC128620A (13 March 2024); https://doi.org/10.1117/12.3009004

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE