CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 10347 > Article
Presentation
25 September 2017 Evanescent single-molecule biosensing with quantum limited precision (Conference Presentation)
Nicolas P. Mauranyapin, Lars Madsen, Michael A. Taylor, Muhammad Waleed, Warwick P. Bowen
Author Affiliations +
Proceedings Volume 10347, Optical Trapping and Optical Micromanipulation XIV; 103470S (2017) https://doi.org/10.1117/12.2276649
Event: SPIE Nanoscience + Engineering, 2017, San Diego, California, United States
Abstract
Techniques to observe and track single unlabelled biomolecules are crucial for many areas of nano-biotechnology; allowing to shed light on important nanoscale biological processes. Impressive progress has been made over the past few years to extend the sensitivity of such techniques, primarily via evanescent field enhancement. However, such approaches expose the biological system to greatly increased optical intensity levels. Here, we introduce an evanescent biosensor that operates at the fundamental quantum limit. This allows a five order-of magnitude reduction in optical intensity whilst maintaining state-of-the-art sensitivity and enabling quantum noise limited tracking of single biomolecules as small as 3.5 nm.
Conference Presentation
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Nicolas P. Mauranyapin, Lars Madsen, Michael A. Taylor, Muhammad Waleed, and Warwick P. Bowen "Evanescent single-molecule biosensing with quantum limited precision (Conference Presentation)", Proc. SPIE 10347, Optical Trapping and Optical Micromanipulation XIV, 103470S (25 September 2017); https://doi.org/10.1117/12.2276649
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
;
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Molecules
Biosensors
Heterodyning
Near field optics
Plasmonics
Biosensing
Diagnostics
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top