Laser-excited gold nanoparticles for treatment of cancer cells in vitro

Noé Zamora-Romero; Vicente Robles; Crysthal Alvarez; Natanael Cuando-Espitia; Luis F. Devia-Cruz; Elias Penilla; David L. Halaney; Guillermo Aguilar

doi:10.1117/12.2286005

1 August 2017 Laser-excited gold nanoparticles for treatment of cancer cells in vitro

Noé Zamora-Romero, Vicente Robles, Crysthal Alvarez, Natanael Cuando-Espitia, Luis F. Devia-Cruz, Elias Penilla, David L. Halaney, Guillermo Aguilar

Author Affiliations +

Proceedings Volume 10417, Medical Laser Applications and Laser-Tissue Interactions VIII; 1041707 (2017) https://doi.org/10.1117/12.2286005
Event: European Conferences on Biomedical Optics, 2017, Munich, Germany

Abstract

Several in vitro and in vivo studies have been performed to investigate the potential of Photothermal Therapy (PTT) as a cancer treatment strategy. However, there are still open questions concerning the optimal parameters for generating cavitation bubbles and acoustic shockwaves for increasing the damage to malignant cells, and the primary mechanism for cell damage in PTT is still a matter of debate. This study investigates PTT based on shockwaves from cavitation induced far from the cells, due to laser absorption by gold nanorods (GNR) colloidal solutions in vitro. The effects of laser energy and distance from the cavitation on cell viability is investigated in PC3 prostate cancer cells, and Escherichia coli (E. coli) cells, respectively.

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Noé Zamora-Romero, Vicente Robles, Crysthal Alvarez, Natanael Cuando-Espitia, Luis F. Devia-Cruz, Elias Penilla, David L. Halaney, and Guillermo Aguilar "Laser-excited gold nanoparticles for treatment of cancer cells in vitro", Proc. SPIE 10417, Medical Laser Applications and Laser-Tissue Interactions VIII, 1041707 (1 August 2017); https://doi.org/10.1117/12.2286005

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