Cryo-micro-optical sectioning tomography for label-free brainwide visualization of senile plaque (Conference Presentation)

Yilin Luo; Anle Wang; Mengmeng Liu; Tian Lei; Xiaochuan Zhang; Zhaobing Gao; Hualiang Liang; Hui Gong; Jing Yuan

doi:10.1117/12.2296253

14 March 2018 Cryo-micro-optical sectioning tomography for label-free brainwide visualization of senile plaque (Conference Presentation)

Yilin Luo, Anle Wang, Mengmeng Liu, Tian Lei, Xiaochuan Zhang, Zhaobing Gao, Hualiang Liang, Hui Gong, Jing Yuan

Author Affiliations +

Proceedings Volume 10481, Neural Imaging and Sensing 2018; 104810M (2018) https://doi.org/10.1117/12.2296253
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Optical visualization of Alzheimer’s disease (AD) pathological changes is crucial to facilitate exploration of disease mechanism and treatment. We developed cryo-micro-optical sectioning tomography (cryo-MOST) to acquire brainwide map of senile plaques. Using intrinsic fluorescence emission intensified under ultra-low temperature, we accomplished senile plaque visualization at a micron-level resolution. A whole-brain coronal distribution of senile plaque in a transgenic mouse was successfully acquired without any exogenous dye. We believe cryo-MOST would be a potential tool for understanding neurodegenerative disease mechanism and evaluating drug efficacy.

Conference Presentation

Citation Download Citation

Yilin Luo, Anle Wang, Mengmeng Liu, Tian Lei, Xiaochuan Zhang, Zhaobing Gao, Hualiang Liang, Hui Gong, and Jing Yuan "Cryo-micro-optical sectioning tomography for label-free brainwide visualization of senile plaque (Conference Presentation)", Proc. SPIE 10481, Neural Imaging and Sensing 2018, 104810M (14 March 2018); https://doi.org/10.1117/12.2296253

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