Voluntary exercise confers protection against age-related deficits in brain oxygenation in awake mice model of Alzheimer’s disease

Xuecong Lu; Mohammad Moeini; Baoqiang Li; Sava Sakadžić; Frédéric Lesage

doi:10.1117/12.2289007

12 February 2018 Voluntary exercise confers protection against age-related deficits in brain oxygenation in awake mice model of Alzheimer’s disease

Xuecong Lu, Mohammad Moeini, Baoqiang Li, Sava Sakadžić, Frédéric Lesage

Author Affiliations +

Proceedings Volume 10481, Neural Imaging and Sensing 2018; 104811G (2018) https://doi.org/10.1117/12.2289007
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by short-term memory loss and cognitive inabilities. This work seeks to study the effects of voluntary exercise on the change in oxygen delivery in awake mice models of Alzheimer’s disease by monitoring brain tissue oxygenation. Experiments were performed on Young (AD_Y, 3-4 months, n=8), Old (AD_O, 6-7 months, n=8), and Old with exercise (AD_OEX, 6-7 months, n=8) transgenic APPPS1 mice and their controls. Brain tissue oxygenation was measured by two photon phosphorescence lifetime microscopy on the left sensory motor cortex. We found that the average tissue PO2 decreased with age but were regulated by exercise. The results suggest a potential for exercise to improve brain function with age and AD.

Citation Download Citation

Xuecong Lu, Mohammad Moeini, Baoqiang Li, Sava Sakadžić, and Frédéric Lesage "Voluntary exercise confers protection against age-related deficits in brain oxygenation in awake mice model of Alzheimer’s disease", Proc. SPIE 10481, Neural Imaging and Sensing 2018, 104811G (12 February 2018); https://doi.org/10.1117/12.2289007

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