Characterisation of a novel transmission Raman spectroscopy platform for non-invasive detection of breast micro-calcifications

Adrian Ghita; Pavel Matousek; Nick Stone

doi:10.1117/12.2297632

13 February 2018 Characterisation of a novel transmission Raman spectroscopy platform for non-invasive detection of breast micro-calcifications

Adrian Ghita, Pavel Matousek, Nick Stone

Author Affiliations +

Proceedings Volume 10490, Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry; 104900G (2018) https://doi.org/10.1117/12.2297632
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Our work focuses on the development of a medical Raman spectroscopy based platform to non-invasively detect and determine in-vivo molecular information deep inside biological tissues by monitoring the chemical composition of breast calcifications. The ultimate goal is to replace a needle biopsy which typically follows the detection of an abnormality in mammographic images. Here we report the non-invasive detection of calcium oxalate monohydrate in tissue through 40 mm of phantom tissues using our recently developed advanced Raman instrument complementing our previous detection of calcium hydroxyapatite through this thickness of tissue. The ability to detect these two key types of calcifications opens avenues for the development of non-invasive in-vivo breast cancer diagnostic tool in the future.

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Adrian Ghita, Pavel Matousek, and Nick Stone "Characterisation of a novel transmission Raman spectroscopy platform for non-invasive detection of breast micro-calcifications", Proc. SPIE 10490, Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry, 104900G (13 February 2018); https://doi.org/10.1117/12.2297632

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KEYWORDS

Tissues

Raman spectroscopy

Breast

Spectroscopy

Breast cancer

In vivo imaging

Diagnostics

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