Silicon ATR crystal with subwavelength structures optimized for blood analysis

Lorenz Sykora; Anja Müller; Alexander Kondratiev; Andreas Roth; Vitalii Mozin; Axel Fehr; Gloria Zörnack

doi:10.1117/12.2513295

27 February 2019 Silicon ATR crystal with subwavelength structures optimized for blood analysis

Lorenz Sykora, Anja Müller, Alexander Kondratiev, Andreas Roth, Vitalii Mozin, Axel Fehr, Gloria Zörnack

Proceedings Volume 10872, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX; 108720F (2019) https://doi.org/10.1117/12.2513295
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Using infrared spectroscopy for blood analysis has a high potential. In order to bring infrared spectroscopy to clinics, a cost-effective sampling approach, high sample throughput, small sample sizes (< 15μl) and a low detection limit are required. A novel ATR crystal with subwavelength structures on the sampling side was developed and fabricated. The structures and the analyte form an effective medium layer, which supports destructive interference. The absorption signal can be enhanced by at least one order of magnitude. The microstructures also act as a micro sieve that replaces blood centrifugation. The enhancement can be optimized for wavelength regions of interest by changing the dimensions of the microstructures. First steps towards the solution of this high dimensional inverse design problem were made with different neural network architectures.

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Citation Download Citation

Lorenz Sykora, Anja Müller, Alexander Kondratiev, Andreas Roth, Vitalii Mozin, Axel Fehr, and Gloria Zörnack "Silicon ATR crystal with subwavelength structures optimized for blood analysis", Proc. SPIE 10872, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX, 108720F (27 February 2019); https://doi.org/10.1117/12.2513295

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