Non-invasive blood glucose measurement using fixed-wavelength quantum cascade lasers

T. Koyama; S. Kino; Y. Matsuura

doi:10.1117/12.2508200

27 February 2019 Non-invasive blood glucose measurement using fixed-wavelength quantum cascade lasers

T. Koyama, S. Kino, Y. Matsuura

Author Affiliations +

Proceedings Volume 10872, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX; 108720A (2019) https://doi.org/10.1117/12.2508200
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

An ATR measurement system composed of hollow optical fibers, a trapezoid multi-reflection prism, and a couple of fixed-wavelength QCLs emitting different wavelengths is proposed for non-invasive measurement of blood glucose. To choose a wavelength combination that is appropriate for measurement of glucose absorption, firstly absorption spectra of human lip mucosa measured by using an FT-IR-based ATR system are investigated. As a result, two wavelengths, 1152 cm^-1 that coincides with an absorption peak of glucose, and 1186 cm-1 where the glucose absorption becomes minimum are chosen. From numerical simulation using spectral absorptions measured by the FT-IR system, it is found that the differential absorption between the above wavelengths shows a good correlation to blood glucose levels. Finally in-vivo measurement using the ATR system equipped with two single-wavelength QCLs is performed and it is found that the measured optical absorption follows the blood glucose well.

Conference Presentation

Citation Download Citation

T. Koyama, S. Kino, and Y. Matsuura "Non-invasive blood glucose measurement using fixed-wavelength quantum cascade lasers", Proc. SPIE 10872, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX, 108720A (27 February 2019); https://doi.org/10.1117/12.2508200

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