Evaluating hydrogels for implantable probes using SERS

Dayle Kotturi; Sureyya Paterson; Victoria Baldock; Yil-Hwan You; Mike McShane

doi:10.1117/12.2506822

7 March 2019 Evaluating hydrogels for implantable probes using SERS

Dayle Kotturi, Sureyya Paterson, Victoria Baldock, Yil-Hwan You, Mike McShane

Author Affiliations +

Proceedings Volume 10894, Plasmonics in Biology and Medicine XVI; 108941B (2019) https://doi.org/10.1117/12.2506822
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Now that a fully-implantable, continuous glucose monitor has received FDA approval, optical techniques other than fluorescence will seek to overcome the limited lifetimes resulting from photobleaching. Using plasmonic nanoparticles, we present the potential of reversible SERS-active sensing assays to function as long-term implantable sensors. The assays offer high selectivity and specificity of analyte detection and concentration without loss of emission intensity over time due to photodestruction. These assays are encapsulated in microdomains bounded by polyelectrolyte multilayers (PEMs), permeable to the target but impermeable to proteins. The microdomains are stabilized in hydrogels for biocompatibility and longevity. This study characterizes the performance of pH-sensitive Raman probes in three different hydrogels in a simulated in vivo environment with changing pH over time.

Citation Download Citation

Dayle Kotturi, Sureyya Paterson, Victoria Baldock, Yil-Hwan You, and Mike McShane "Evaluating hydrogels for implantable probes using SERS", Proc. SPIE 10894, Plasmonics in Biology and Medicine XVI, 108941B (7 March 2019); https://doi.org/10.1117/12.2506822

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