Generation and monitoring of cavitation with an optical resolution photoacoustic microscope

G. Paltauf; R. Nuster

doi:10.1117/12.2526717

19 July 2019 Generation and monitoring of cavitation with an optical resolution photoacoustic microscope

G. Paltauf, R. Nuster

Author Affiliations +

Proceedings Volume 11077, Opto-Acoustic Methods and Applications in Biophotonics IV; 110770X (2019) https://doi.org/10.1117/12.2526717
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

An optical resolution photoacoustic microscopy (OR-PAM) setup was used to generate transient cavitation on a strongly absorbing target. The cavitation bubble dynamics were monitored with an optical probe beam, which was guided collinearly and confocally with the excitation laser pulses. Simultaneously, the acoustic transients occurring during initiation and collapse of the bubbles were measured with a probe beam deflection method. With 25 nJ pulse energy, cavitation bubbles of 15 to 20 μm maximum diameter were generated around a carbon fiber. Bubble properties, such as its expansion speed and lifetime were observed with the optical signal, which showed oscillations caused by interference after reflection at the bubble walls. The acoustic signal provided additional measurements of the bubble lifetime. The proposed method can be used to investigate the influence of cavitation on the acoustic OR-PAM signal and to monitor theranostic applications of cavitation bubbles.

Citation Download Citation

G. Paltauf and R. Nuster "Generation and monitoring of cavitation with an optical resolution photoacoustic microscope", Proc. SPIE 11077, Opto-Acoustic Methods and Applications in Biophotonics IV, 110770X (19 July 2019); https://doi.org/10.1117/12.2526717

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