Magnetic particle composites as a non-invasive high-resolution brain-machine interface (Conference Presentation)

Irving N. Weinberg; Lamar O. Mair; Sahar Jafari; Chad Ropp; Olivia Hale; Anjana Hevaganinge; Rutuja Kulkarni; Fair Vassoler; Luz Martinez-Miranda

doi:10.1117/12.2532453

9 September 2019 Magnetic particle composites as a non-invasive high-resolution brain-machine interface (Conference Presentation)

Irving N. Weinberg, Lamar O. Mair, Sahar Jafari, Chad Ropp, Olivia Hale, Anjana Hevaganinge, Rutuja Kulkarni, Fair Vassoler, Luz Martinez-Miranda

Author Affiliations +

Proceedings Volume 11087, Biosensing and Nanomedicine XII; 1108708 (2019) https://doi.org/10.1117/12.2532453
Event: SPIE Nanoscience + Engineering, 2019, San Diego, California, United States

Abstract

We are developing a voltage-sensitive magnetic resonance imaging (MRI) contrast agent capable of detecting neuronal activity deep within the brain, as well as sensing activation in the peripheral nervous system. The contrast agent will allow nervous system activity to be read out by an external device, with spatial resolution of 30 microns and temporal resolution of 10 milliseconds. The field sensitivity appears to be as low as 20 volts/meter, which is several orders of magnitude higher than the sensitivity of optical contrast agents. We have also validated that injection of a similar particle can be used to initiate behavioral changes in mice upon application of an external changing magnetic field. The external field is about 10 mT, which can be produced with a wearable device. We have also validated the ability to magnetically inject particles into the brain (in mice) intra-nasally, with efficiency that is several hundred times higher than non-magnetic inhalation. The combination of these two products will be useful as a neuroscience/neuroengineering imaging tool, a clinical diagnostic tool, and, in the future, as a robust brain-machine interface

Conference Presentation

Citation Download Citation

Irving N. Weinberg, Lamar O. Mair, Sahar Jafari, Chad Ropp, Olivia Hale, Anjana Hevaganinge, Rutuja Kulkarni, Fair Vassoler, and Luz Martinez-Miranda "Magnetic particle composites as a non-invasive high-resolution brain-machine interface (Conference Presentation)", Proc. SPIE 11087, Biosensing and Nanomedicine XII, 1108708 (9 September 2019); https://doi.org/10.1117/12.2532453

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