Optical fiber based in-vivo oxidative stress biosensor

Roman Kostecki; Bin Zhang; Abdeljalil El Habti; Azim Arman; Mark R. Hutchinson; Penny J. Tricker; Delphine Fleury; Roger J. Narayan; Heike Ebendorff-Heidepriem

doi:10.1117/12.2539920

30 December 2019 Optical fiber based in-vivo oxidative stress biosensor

Roman Kostecki, Bin Zhang, Abdeljalil El Habti, Azim Arman, Mark R. Hutchinson, Penny J. Tricker, Delphine Fleury, Roger J. Narayan, Heike Ebendorff-Heidepriem

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Proceedings Volume 11202, Biophotonics Australasia 2019; 112020R (2019) https://doi.org/10.1117/12.2539920
Event: ANZCOP, 2019, Melbourne, Australia

Abstract

Oxygen metabolism is a necessary process that takes place in animals and plants. Our cells and plant cells produce free radicals known as reactive oxygen species (ROS) continuously as a byproduct of oxygen metabolism and reaction to various environmental stresses, which must be normalized to avoid oxidative stress. Oxidative stress is intimately linked to cellular energy balance and occurs when there’s an imbalance between production and accumulation of ROS in cells and tissues and the ability of a biological system to keep in a redox steady state. We show preliminary results of an optical fiber based reversible in-vivo biosensor for understanding redox balance within living systems. The biosensor measured protein carbonyls (a marker of oxygen metabolism and oxidative stress) in pig-skin, live mouse, and wheat plant.

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Roman Kostecki, Bin Zhang, Abdeljalil El Habti, Azim Arman, Mark R. Hutchinson, Penny J. Tricker, Delphine Fleury, Roger J. Narayan, and Heike Ebendorff-Heidepriem "Optical fiber based in-vivo oxidative stress biosensor", Proc. SPIE 11202, Biophotonics Australasia 2019, 112020R (30 December 2019); https://doi.org/10.1117/12.2539920

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KEYWORDS

Biosensors

Proteins

In vivo imaging

Optical fibers

Oxygen

Sensors

Blood

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