Investigation of adsorption and release of photodynamic dyes by Clinoptilolite zeolite

Anupama Nair; V. A. Hovhannisyan; Shean-Jen Chen

doi:10.1117/12.2546905

16 March 2020 Investigation of adsorption and release of photodynamic dyes by Clinoptilolite zeolite

Anupama Nair, V. A. Hovhannisyan, Shean-Jen Chen

Author Affiliations +

Proceedings Volume 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX; 112200G (2020) https://doi.org/10.1117/12.2546905
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

This study investigated the use of clinoptilolite zeolites (CZs) as the drug adsorbent and their ability to release 5- Aminolevulinic acid (5-ALA) and porphyrin (Zn-TBut3 PyP) in the presence of biomolecules, by absorption and fluorescence spectrometry and multiphoton spectroscopy. About one-third of the porphyrin adsorbed on to CZs was released in the presence of biomolecule such as insulin. In-vitro measurements show that the skin absorbed the dye more than 1.5 times for ALA-CZ and porphyrin-CZ complex compared to non-CZ form. The measurements on chicken skin were also performed using multiphoton microscopy which compared the penetration of the dye into the skin in the presence and absence of CZ. These results demonstrate the potential of CZ in the efficient adsorption and biomolecule favoured release of 5-ALA and porphyrin in biological systems.

Conference Presentation

Citation Download Citation

Anupama Nair, V. A. Hovhannisyan, and Shean-Jen Chen "Investigation of adsorption and release of photodynamic dyes by Clinoptilolite zeolite", Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200G (16 March 2020); https://doi.org/10.1117/12.2546905

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