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Cerebrovascular Autoregulation failure is known to allow drastic changes in cerebral blood flow in cases of extreme Cerebral Perfusion Pressure (CPP) or Intracranial Pressure (ICP). Brain pathologies (such as traumatic brain injury, hydrocephalus, stroke, etc.) which alter CPP and ICP are also known to show impaired neurovascular coupling. We analyzed these characteristic changes in neurovascular coupling in a model to develop a non-invasive diagnostic marker of autoregulation failure using EEG, Near-Infrared Spectroscopy and Diffuse Correlation Spectroscopy.
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Deepshikha Acharya, Alexander Ruesch, Jason Yang, Samantha Schmitt, Jana Kainerstorfer, Matthew Smith, "Role of cerebrovascular autoregulation in neurovascular coupling (Conference Presentation)," Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260Y (9 March 2020); https://doi.org/10.1117/12.2546760