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Optical coherence tomography (OCT) allows for imaging of fine structures below the surface of tissue based on inherent contrast from heterogeneity of optical refractive index. A contrast agent may be used when intrinsic contrast of a target in the sample is not enough. We synthesize magnetically-responsive nanorods whose reflectivity can be modulated by the orientation of a magnetic field and demonstrate their use in background-free OCT imaging. Because normal tissue does not respond to switching magnetic field, the signal from nanorods can be isolated from tissue.
Wesley Poon,Zhiwei Li,Boris H. Park, andYadong Yin
"Background-free optical coherence tomography imaging with gold-seeded growth on magnetically responsive nanorods (Conference Presentation)", Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112282D (9 March 2020); https://doi.org/10.1117/12.2545754
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Wesley Poon, Zhiwei Li, Boris H. Park, Yadong Yin, "Background-free optical coherence tomography imaging with gold-seeded growth on magnetically responsive nanorods (Conference Presentation)," Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112282D (9 March 2020); https://doi.org/10.1117/12.2545754