Zachary S. Ballard,1 Sarah Bazargan,1 Diane Jung,1 Shyama Sathianathan,1 Ashley Clemens,1 Daniel Shir,1 Saba Al-Hashimi,2 Aydogan Ozcanhttps://orcid.org/0000-0002-0717-683X1
1Univ. of California, Los Angeles (United States) 2UCLA Stein Eye Institute (United States)
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We demonstrate a contact-lens (CL) based mobile sensing system which can be used to measure protein levels in human tear. By using a cost-effective mobile-phone-based well-plate reader and a fluorescent assay, we quantify lysozyme nonspecifically bound to CLs. We monitored the lysozyme levels of 9 healthy volunteers to establish individual baselines, and then compared these measurements to participants who had been diagnosed with Dry Eye Disease (N=6), observing a statistically significant difference in their means. Due to its non-invasive and simple operation, this method could be used for tear-based sensing and health monitoring applications in point-of-care settings and at home.
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Zachary S. Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan Ozcan, "Contact lens-based lysozyme detection in tear using a mobile and cost-effective sensor (Conference Presentation)," Proc. SPIE 11230, Optics and Biophotonics in Low-Resource Settings VI, 112300R (9 March 2020); https://doi.org/10.1117/12.2546656