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5 March 2021 Ex-vivo investigation on resolution limits for endoscopic optical coherence tomography for pituitary gland and adenoma differentiation
Fabian Placzek, Ryan Sentosa, Roger Fonollà Navarro, Alexander Micko, Michael Winklehner, Romana Höftberger, Marco Andreana, Angelika Unterhuber, Wolfgang Drexler, Stefan Wolfsberger, Rainer Andreas Leitgeb
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Proceedings Volume 11620, Endoscopic Microscopy XVI; 116200F (2021) https://doi.org/10.1117/12.2579563
Event: SPIE BiOS, 2021, Online Only
Abstract
Using optical coherence tomography (OCT) intraoperatively for pituitary gland and adenoma differentiation, might lead to a more distinct resection of tumor tissue. Therefore, more gland tissue would be preserved and invasively grown adenoma tissue can be detected and removed. We evaluate the feasibility of laser scanning microscope based OCT for differentiation of healthy and tumor tissue on biopsies resected during surgery. The OCT images are compared to histopathological results. Resolution reduced OCT images are automatically analyzed to estimate the performance parameters for a possible endoscopic translation.
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Fabian Placzek, Ryan Sentosa, Roger Fonollà Navarro, Alexander Micko, Michael Winklehner, Romana Höftberger, Marco Andreana, Angelika Unterhuber, Wolfgang Drexler, Stefan Wolfsberger, and Rainer Andreas Leitgeb "Ex-vivo investigation on resolution limits for endoscopic optical coherence tomography for pituitary gland and adenoma differentiation", Proc. SPIE 11620, Endoscopic Microscopy XVI, 116200F (5 March 2021); https://doi.org/10.1117/12.2579563
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KEYWORDS
Optical coherence tomography
Endoscopy
Image resolution
Tissues
Tumors
Real time imaging
Surgery
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