Bruch’s membrane (BM) is a pentalaminar structure that mediates transport between the retinal pigment epithelium (RPE) and choriocapillaris. With near-infrared Optical Coherence Tomography (OCT), it has been challenging to visualize, let alone quantify, BM non-invasively in non-pathologic eyes. First, we show that shorter wavelength visible light OCT consistently delineates BM better than longer wavelength visible light OCT in pigmented human subjects, independent of axial resolution. Second, we develop a physical model of RPE and BM reflectivity to explain this finding. Third, we employ this model to devise a morphometric algorithm to more accurately map BM thickness in the normal macula.
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