Contributions of diffuse and directed flow in turbid media to absolute measurements of tissue perfusion and oxygen consumption using laser speckle and spatial frequency domain imaging

Robert H. Wilson; Christian Crouzet; Afsheen Bazrafkan; Masih A. Rafi; Yama Akbari; Bernard Choi

doi:10.1117/12.2579039

5 March 2021 Contributions of diffuse and directed flow in turbid media to absolute measurements of tissue perfusion and oxygen consumption using laser speckle and spatial frequency domain imaging

Robert H. Wilson, Christian Crouzet, Afsheen Bazrafkan, Masih A. Rafi, Yama Akbari, Bernard Choi

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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116290E (2021) https://doi.org/10.1117/12.2579039
Event: SPIE BiOS, 2021, Online Only

Abstract

We describe the development of a perturbation-free technique to measure tissue blood flow and metabolic rate of oxygen (MRO2) using LSI and SFDI. Analytical (diffusion) and computational (Monte Carlo) models are employed to characterize the contributions of diffuse and directed flow to the measured speckle contrast. Measured flow data is combined with the deoxygenated hemoglobin concentration and a path-length factor (both obtained from SFDI) to model tissue oxygen consumption in units of M O2/min. The results of this model were comparable with values of MRO2 measured with other imaging methods (PET, MRI/MRS).

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Robert H. Wilson, Christian Crouzet, Afsheen Bazrafkan, Masih A. Rafi, Yama Akbari, and Bernard Choi "Contributions of diffuse and directed flow in turbid media to absolute measurements of tissue perfusion and oxygen consumption using laser speckle and spatial frequency domain imaging", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116290E (5 March 2021); https://doi.org/10.1117/12.2579039

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