Frequency selection in frequency domain diffuse optical spectroscopy

Matthew B. Applegate; Carlos A. Gómez; Darren Roblyer

doi:10.1117/12.2578377

5 March 2021 Frequency selection in frequency domain diffuse optical spectroscopy

Matthew B. Applegate, Carlos A. Gómez, Darren Roblyer

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116390N (2021) https://doi.org/10.1117/12.2578377
Event: SPIE BiOS, 2021, Online Only

Abstract

Frequency domain diffuse optical spectroscopy (FD-DOS) is a non-invasive technique used to determine the optical absorption and reduced scattering coefficients of biological tissue. Incident light is modulated at radio frequencies and the amplitude and phase shift induced by tissue are analyzed. Here, we evaluate different modulation frequency selection schemes using simulated data. We used noise-free data to evaluate the inverse model, and noisy data using instrument-specific noise models. We found that careful tuning of the inversion algorithm parameters is required to achieve good results and adding modulation frequencies can sometimes result in worse performance depending on the instrument.

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Matthew B. Applegate, Carlos A. Gómez, and Darren Roblyer "Frequency selection in frequency domain diffuse optical spectroscopy", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116390N (5 March 2021); https://doi.org/10.1117/12.2578377

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