Multiphoton imaging of the fluorescent advanced glycation end products in tissues

Chih-Ju Lin; Jeon Woong Kang; Peter. T. C. So; Chen-Yuan Dong

doi:10.1117/12.2583608

25 March 2021 Multiphoton imaging of the fluorescent advanced glycation end products in tissues

Chih-Ju Lin, Jeon Woong Kang, Peter. T. C. So, Chen-Yuan Dong

Proceedings Volume 11648, Multiphoton Microscopy in the Biomedical Sciences XXI; 1164816 (2021) https://doi.org/10.1117/12.2583608
Event: SPIE BiOS, 2021, Online Only

Abstract

Advanced glycation end products (AGEs) contribute to diabetic complications. Proteins undergo a series of complex and chain of biochemical actions in producing AGEs, some of which are fluorescent. In our study, we investigated the effects of glucose, fructose, and galactose in forming AGEs. Porcine tissues such as corneas, tendons, skin, aortas, and kidney were treated in the D-glucose, D-galactose, and D-fructose solutions, and multiphoton microscopy was performed on the glycated tissue specimens. We found that the rate of fAGEs formation from fructose was the highest.

Conference Presentation

Citation Download Citation

Chih-Ju Lin, Jeon Woong Kang, Peter. T. C. So, and Chen-Yuan Dong "Multiphoton imaging of the fluorescent advanced glycation end products in tissues", Proc. SPIE 11648, Multiphoton Microscopy in the Biomedical Sciences XXI, 1164816 (25 March 2021); https://doi.org/10.1117/12.2583608

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