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Structured illumination microscope enables high temporal resolution wide field-of-view super-resolution imaging but typically provides only two-fold resolution improvement over the diffraction limit. We present speckle metamaterial-assisted illumination nanoscopy (MAIN) which brings the resolution down to 40 nm and beyond. A hyperbolic metamaterial is implemented as a substrate to generate subwavelength illumination patterns in the near field of the metamaterial. Fluorescent objects located on the metamaterial are illuminated by such high spatial-frequency near field illuminations and are reconstructed by a Blind-SIM algorithm. Speckle-MAIN represents a new route for super-resolution, which may lead to important applications in bio-imaging and surface characterization.
Zhaowei Liu
"Metamaterial assisted illumination nanoscopy using super-resolution speckles", Proc. SPIE 11654, High-Speed Biomedical Imaging and Spectroscopy VI, 116540M (5 March 2021); https://doi.org/10.1117/12.2582578
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