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9 March 2021 Multimodal super-resolution nanoimaging & nanomanipulation of plasmonic nanoparticles
Yunbo Liu, Zhijia Zhang, Guangjie Cui, Xintao Zhao, Somin Eunice Lee
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Proceedings Volume 11661, Plasmonics in Biology and Medicine XVIII; 116610H (2021) https://doi.org/10.1117/12.2578362
Event: SPIE BiOS, 2021, Online Only
Abstract
Fluorescence super-resolution imaging relies on fluorophores as contrast agents. As a result of the inevitable photobleaching and thus a limited photon budget, they put fundamental limitations on the temporal resolution. We propose non-bleaching, plasmonic nanoparticles as non-bleaching contrast agents with an unlimited photon budget such that both the temporal and spatial resolution can be pursued at the same time. We demonstrated a continuous observation of fine structural features in resolved actin networks. We believe the non-bleaching nanoscale imaging will open new doors for observing biological processes on a much longer timescales with higher spatial and temporal details.
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Yunbo Liu, Zhijia Zhang, Guangjie Cui, Xintao Zhao, and Somin Eunice Lee "Multimodal super-resolution nanoimaging & nanomanipulation of plasmonic nanoparticles", Proc. SPIE 11661, Plasmonics in Biology and Medicine XVIII, 116610H (9 March 2021); https://doi.org/10.1117/12.2578362
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KEYWORDS
Super resolution
Luminescence
Nanoparticles
Plasmonics
Spatial resolution
Temporal resolution
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