Optical bacteriophage susceptibility testing by SPR (surface plasmon resonance)

Larry O'Connell; Yoann Roupioz; Pierre Marcoux

doi:10.1117/12.2578753

5 March 2021 Optical bacteriophage susceptibility testing by SPR (surface plasmon resonance)

Larry O'Connell, Yoann Roupioz, Pierre Marcoux

Author Affiliations +

Proceedings Volume 11661, Plasmonics in Biology and Medicine XVIII; 116610O (2021) https://doi.org/10.1117/12.2578753
Event: SPIE BiOS, 2021, Online Only

Abstract

The proliferation of multiresistant bacteria is having an increasing and profound impact on the world. A credible alternative to antibiotics is bacteriophage therapy, which are expected in the near future to form the basis of an entirely new treatment paradigm for infectious diseases. In order to facilitate such an epochal transition, new tools are needed for the rapid and multiplexed screening of large libraries of candidate bacteriophages in order to provide a personalized bacteriophage cocktail for each patient. This talk presents recent progress towards the development of a SPR-based screening method, wherein immobilized bacteriophages form a biosensing layer which produces a measurable surface plasmon resonance signal as a result of the specific interaction between the bacteriophages and their host bacterial cells in a microfluidic flow above the sensor surface.

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Citation Download Citation

Larry O'Connell, Yoann Roupioz, and Pierre Marcoux "Optical bacteriophage susceptibility testing by SPR (surface plasmon resonance)", Proc. SPIE 11661, Plasmonics in Biology and Medicine XVIII, 116610O (5 March 2021); https://doi.org/10.1117/12.2578753

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